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Vitamin B12: Advances and Insights by Rima Obeid2017 | ISBN: 1498706991 | English | 376 pages | PDF | 5 MBCobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was, however, based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently, the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet, environment and diseases. Conditions like aging, diet and drugs increase the risk of developing cobalamin deficiency, probably because of diminished ability to liberate, absorb or distribute the food-derived vitamin. From a basic science point of view, understanding of the transport and function of the vitamin, may pave the road for using this system for drug delivery.This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifaceted aspects of the vitamin in health and disease conditions. The book has been written by leading scientists who have significant contributions in this field and represents therefore, a timely unique encyclopaedia on cobalamin. Table of ContentsMilestones in the Discovery of Pernicious Anemia and Its TreatmentJörn SchneedeNutritional and Biochemical Aspects of Cobalamin throughout LifeEva GreibeIntracellular Processing and Utilization of CobalaminsLuciana Hannibal and Donald W. JacobsenInherited Defects of Cobalamin metabolismDavid Watkins and David S. RosenblattConditions and Diseases that Cause Vitamin B12 Deficiency: Form metabolism to DiseasesEmmanuel AndrèsVitamin B12 Deficiency in Developing and Newly Industrialising CountriesChittaranjan Yajnik, Urmila Deshmukh, Prachi Katre and Tejas LimayeVitamin B12 in Neurology and AgingAndrew McCaddon and Joshua W MillerThe Role of Cobalamin in the Central and Peripheral Nervous Systems: Mechanistic InsightsElena MuttiLaboratory Markers and Diagnosis of Cobalamin DeficiencyRima ObeidCobalamin during Pregnancy and LactationRima Obeid, Pol Solé-Navais and Michelle M MurphyVitamin B12 after Birth and during Early LifeRima Obeid, Pol SoléNavais and Michelle M MurphyCobalamin – Folate InteractionsPol Solé-Navais, Rima Obeid and Michelle M MurphyExtreme Vitamin B12 Concentrations in Clinical Practice in the Absence of Symptoms or B12 TreatmentRima ObeidVitamin B12 and Drug DevelopmentJayme L. Workinger and Robert P. Doylehttp://www.crcpress.com/Vitamin-B12-Advances-and-Insights/Ob…