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ONCOGENE AND CANCER – FROM BENCH TO CLINICEdited by Yahwardiah Siregar .496 pages .****This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors******It took a long journey to really understand what cancer is, although many researcher are still working of finding a definite answer on how to treat cancer, and, what is more important, how to detect cancer very early, when some cells start going abnormal and transform into cancer cells.The immune system might be the best weapon against cancer, since immune defense is programmed to recognize and destroy abnormal cells, but cancer cells may develop many defenses against immune attacks. Advances in biological processes, including apoptosis and cell proliferation, that are known to be dysregulated in tumors need to be understood in molecular mechanisms. During the last decade, scientists have shown an interest to create cancer vaccines as well as DNA vaccines using development of new biotechnological tools to elucidate an immune attack against cancer.Recently, a new players in cancer biology have appeared: microRNAs (miRs or miRNAs), a class of small non-coding RNAs that play important roles in cell differentiation, cell growth and cell death. miRNAs can act either as oncogenes or tumor suppressors and regulate the interaction between cancer cells and the microenvironment. Understanding the function of ncRNAs by focusing on the potential involvement of specific RNA species, such as microRNAs, small nucleolar RNAs, Piwi-interacting RNA, long non-coding RNAs, in the development andprogression of cancer is described in this book.The book was written not only for medical students, but it can also be widely used by clinical and biomedical scientists, as well as by doctors studying for their postgraduate research.My thanks are specifically aimed at Intech Open staff (Ms. Reinic, Ms. Blecic, Mr.Greblo and Ms Zgela) who helped finish this book. I would also like to express my thankfulness to all authors who contributed a chapter to this publication. Finally, I hope this book will be useful to the health of mankind worldwide.Yahwardiah Siregar- See more at: http://medicaltextboks.blogspot.ru/2013/01/Biochemistry-Gene…