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PREFACE It would take a superhuman ability to explore the deeper foundations of life. What one can do, more hopefully, is to investigate just a few of its facets. This booklet is a very personal account of some of my own researches. It is neither complete nor continuous. I have omitted even much of my own work. No mention is made, for instance, of my work on metabolism, the C4 dicarboxylic acid catalysis which was honored by the Nobel Prize and which has led to the Krebs cycle. References will be found at the end of each chapter. I have tried to summarize the work of authors who have done extensive research. In its early phases my research was generously sup-ported by the National Institutes of Health. My thanks are due to all those who have helped to keep me “above water” since, particularly the Josephine B. Crane Foun-dation. My thanks are also due to the National Science Foundation (Grant GB 29395) and to the L. and L. Foundation. I gratefully acknowledge the assistance of my faithful associates Miss Jane A. McLaughlin and Miss Barbara Perry, and of Dr. L. S. Egyiid. I also want to thank my friend Dr. John Platt for his painstaking criti-cism. Last, but not least, I owe a debt of gratitude to the Marine Biological Laboratory, Woods Hole for providing me with a scientific home. Please contribute back by OCRing and Spellcheck/Proofreading this book. I recommend ABBYY Finereader 11 (or similar) for doing this work in a relatively easy way. If you plan to do that please leave a comment here so the effort won’t be duplicated by others. Please upload back the final pdf. Thank you.Please note that the high quality scan images are posted here for a specific purpose – to make it easy to OCR/spellcheck the book and not spend 100 hours doing that from a crappy, lossy compressed pdfs that are sometimes posted here. So please don’t waste your time asking why this is not a pdf file. Instead please contribute a few hours of your time and OCR and proofread the posted book. Thank you.